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https://colab.research.google.com/drive/1l-zj3oJ7VukeYQXqS8UQH_kVnKdLkY4a
https://colab.research.google.com/drive/1xK-7aQWdisdBJKKSY6fD-eYCpKvuD-tR
https://colab.research.google.com/drive/1XcWG6iHSjlnXU_hZqHJLOxGcAukETQ4k
https://colab.research.google.com/drive/1uOptXXlwiIO-cOL2_9YztIJm5Ofm-giM
https://colab.research.google.com/drive/1CpQ0YOqckpqnKLC-P79Jw3mEW3REeKMS
You can download it from here.. Browse download page for more details.. Get AdBot Pro Free from bot-cave.net. Botcave.net is a free.1. Field of the Invention
This invention is directed to compounds which are useful for treating pathologies related to decreased chemokine receptor activity and are useful for treating, for example, asthma, rheumatoid arthritis, inflammatory bowel disease, and Alzheimer””s Disease. Compounds of this invention inhibit chemokine receptor activity by binding with the chemokine receptors and thereby inhibit the migration and binding of white blood cells.
2. References
The following publications, patent applications and patents are cited in this application as superscript numbers:
1 Hoeh et al., DNA Cell Biol., 12:131-142 (1993)
2 Neote et al., Cell, 72:415-425 (1993)
3 Gao et al., J Exp. Med., 177:1421-1427 (1993)
4 Neote et al., FASEB J., 7:163-170 (1993)
5 Chin et al., J. Biol. Chem., 269:26031-26037 (1994)
6 Boster et al., Proc. Natl. Acad. Sci. USA, 92:11980-11984 (1995)
7 Englbrecht et al., Eur. J. Immunol., 24:1404-1410 (1994)
8 Osborn et al., Cell, 73:187-198 (1993)
9 Lee et al., WO 95/21613
10 Lawrence et al., EP 575,022
11 Wong et al., J. Biol. Chem., 267:8621-8627 (1992)
12 Cioce et al., J. Biol. Chem., 267:15590-15593 (1992)
13 Stuhl et al., Cell, 65:659-670 (1991)
14 Bachelerie et al., Exp. Hematol., 22:573-581 (1994)
15 Groner et al., J. Exp. Med., 177:1403-1411 (1993)
16 Yednock et al., Nature, 356:63-66 (1992)
17 Strieter et al., J. Immunol., 152:5208-5215 (1994)
18 Julin et al., Biochem. Biophys. Res. Commun., 202
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